Recently we stumbled over this nice Engine called Unity3D.
Since we are planning to make Games for PC and Consoles/Handhelds, and this Engine supports WiiU, PS3, XBox 360, iOS, Android and some more, and makes it easy to port Projects, it is just perfect for us.
It is used by Professional Game Developers and was even recommended to me by Nintendo itself (i asked for some Infos on DevKits and such).
Also, it makes working relatively easy, and we can use C#, which makes our Programmer mobychan very happy.
The only thing that gives us a headache right now is Cel-Shading. Not that it is hard in general, but to make Terrains Cel-Shading is a bit tricky, but well, we just started, so we will find a solution in the next days.
If you seriously wanna make Games, i recommend this Engine.